Alper Karagöl is a researcher and final-year medical student (intern doctor) at Istanbul Medical Faculty. He spent six months as a visiting medical student at UCL Medical School, Royal Free Hospital, where he also collaborated with the Darwin Building. His work integrates molecular evolution, bioinformatics, biophysics, and structural biology to investigate transmembrane proteins and their evolutionary trajectories. Karagöl employs molecular dynamics (MD) simulations, lipid profiling, and variational dynamics to study membrane protein adaptation and function. Under the guidance of Shuguang Zhang from Massachusetts Institute of Technology (MIT), he had worked on water-soluble variants of neurotransmitter transporters and immunomodulatory proteins, applying computational and evolutionary approaches to understand their structural and functional properties. His studies have introduced stochastic game-theory frameworks for analyzing amino acid substitution patterns. Karagöl has authored multiple peer-reviewed articles on protein evolution, transmembrane proteins, and asymmetric mutational dynamics. He holds four pending patents on protein design and truncated isoforms. His research has broad implications for understanding membrane protein adaptation, improving drug target discovery, and advancing computational protein design. He has been awarded numerous fellowships and 7-year scholarship from Turkish Scientific Research Council and awarded honors from Istanbul University (ranked 1st among 450 MD students). In 2019, he ranked in the 0.015th percentile among 2.3 million Turkish students. Karagöl also advocates for animal rights and public engagement in science and mentors high school students from underrepresented regions of Turkey.